Laboratory of Systems and Synthetic Microbiology

Bakshi Lab, Department of Engineering, University of Cambridge

We are actively engaged in the analysis (systems microbiology) and engineering (synthetic microbiology) of microbial systems for various fundamental and applied purposes.

Our primary tools are - molecular biology, single-cell microfluidics, time-lapse microscopy, and machine-learning. We leverage these tools synergistically to investigate: How does noise in regulatory networks and environmental fluctuations contribute to dynamic heterogeneity at the cellular level? How does physiological diversity among cells influence population dynamics over both short and long timescales, including evolutionary processes?

Our primary research focus is to apply this approach for developing a comprehensive understanding of the processes underlying the emergence of antimicrobial resistance (AMR) in microbes, and for engineering modified microbes (bacteria and viruses) to tackle resistant infections.